The state of Chiapas has a total population of 5 217 908 inhabitants, of whom 74.7% live in poverty and 33.5% lack access to health services. The use of HOMA-IR in routine clinical diagnosis has allowed observing that reference values range from 2.6 to 3.8 in adult and pediatric populations in different regions of the world 6 - 9 therefore, determining reference values for specific populations is highly suggested.
4 The first two use fasting glucose and insulin levels to establish a diagnosis, and the third is based on a relationship of fasting triglyceride and insulin levels. Other methods have been developed to determine IR indirectly, including Homeostatic Model Assessment Insulin Resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI) and the McAuley Index. To this end, the standard method used is the euglycemic clamp, which evaluates fasting glucose regulation based on insulin concentrations in vivo 3 however, this method is costly and invasive, and this hinders the frequency of its use in clinical practice. 1 IR has been described as a major risk factor for type 2 diabetes mellitus and cardiovascular disease, conditions that have high morbidity and mortality rates, which explains its diagnostic importance. Insulin resistance (IR) is defined as a decreased response to the effect of the hormone, mainly on the liver, skeletal muscle and adipose tissue, and its pathophysiology has been strongly associated with the etiology of obesity. Palabras clave: Resistencia a la insulina, Obesidad, Diabetes mellitus tipo 2 (DeCS). El HOMA-IR se correlacionó positivamente con la edad (r=0.636), el peso (r=0.569), la talla (r=0.578) y el IMCp (r=0.198).Įn la población de estudio, el HOMA-IR presenta una correlación moderadamente significativa con el aumento del IMCp.
Se encontró una prevalencia combinada de obesidad y sobrepeso de 66% con valores de insulina (p=0.010) y de HOMA-IR (p=0.015) más elevados que los del grupo de peso normal.
Se determinó sobrepeso y obesidad por IMCp en 112 pacientes pediátricos (5-19 años) se determinaron concentraciones de glucosa y de insulina sérica para estimar el HOMA-IR. En pediatría, su morbimortalidad resalta la importancia diagnóstica con fines de atención primaria.ĭeterminar los valores del homeostatic model assessment insulin resistance (HOMA-IR) y su relación con el índice de masa corporal percentil (IMCp) en niños y adolescentes de la región Soconusco, Chiapas.Įstudio transversal. La resistencia a la insulina es un factor importante en el desarrollo de diabetes mellitus tipo 2 y de enfermedades cardiovasculares. Keywords: Insulin Resistance+ Obesity+ Diabetes mellitus type 2 (MeSH). The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198).Ĭonclusions: In the study population, HOMA-IR has a moderately significant correlation with an increase in BMI percentile.
Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of112 children (5-19 years old). Materials and methods: Cross-sectional study. Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care. Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases.
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